GUIDELINES FOR RATS AND MICE . )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. No. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. These rodents are social species and should be housed together, unless scientifically justified for individual housing. 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. endobj There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. … Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. no extended weaning is allowed if post-partum estrus is used. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. is recommended for principles of rabbit pen design. School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. OpenURL . 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. in. 2012). Guidelines for Transgenic Research. Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. No, although OLAW encourages institutions to implement the new guidelines as soon as possible, the review of already approved protocols can be phased in as part of the review processes already in place at Assured institutions. The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Copy Generated on: January 25, 2021, 5:38 am, Guidelines for Documenting Scientific Justification for Exceeding Cage Densities, Maximum Housing Densities for Rat and Mouse Cages, Guidelines on Anesthesia and Analgesia in Ruminants, Guidelines on Administration of Substances to Laboratory Animals, Guidelines on Use of Streptozotocin in Rodents, Guidelines on Adjuvant Use in Rabbits Rats and Mice, The Regents of the University of Michigan. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Unit for Laboratory Animal Medicine (ULAM) Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). However, attempts to assess the effectiveness of specific pathogen-free (SPF 1) housing, husbandry, and health care have been sparse. Keyphrases. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Phone: (734) 764-0277 In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Breeding trios (one male, two females) in a 100 sq. This does not apply to: Littermates that have been cage mates since birth. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. Institutional Animal Care and Use Committee . 䍫�����Q1Md:UdVDJ��*� Authorization for Animal Housing and Special Services Costs. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. These rodents are social species and should be housed together, unless scientifically justified for individual housing. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) Code of practice for the housing and care of. Many experimental approaches require housing rodents in individual cages, including in epilepsy research. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. Guideline No. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. cage ("standard" rat cage). Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modifications have been studied. endobj The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. It is suggested that the housing of laboratory rodents … Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. A.L Hargreaves. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Some strains are more aggressive than others, and fight regardless of the age at combination. This does not apply to: Littermates that have been cage mates since birth. Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. Q�N���e9k��DjϋY�O��� �!�=� Use a clean cage when combining males from different litters to prevent territorial behavior. 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